Neurobium C60

Neurobium and its applications in Biotechnology field

The NEUROBIUM C60™ is a specialized research-grade fullerene C60, designed for use in pharmaceutical and biotechnology studies. Featuring a distinctive hollow carbon cage, it serves as a multi-radical scavenger, effectively neutralizing both reactive oxygen and nitrogen species. It is engineered to imitate the function of natural antioxidant enzymes like superoxidedismutase (SOD) [Ref. 4].

Synthesized via a Solvent-Free Method. [1]

Green chemistry.

Environmentally friendly synthesis using renewable energy. [2]

[1] Solvents and volatiles are removed by subjecting the C60 to a controlled heat-cool process under dynamic inert medical nitrogen in order to suppress oxidation and preserve its pristine nature.
[2] Hydroelectric powered plant in Quebec.

Neurobium C60 Applications in Biotech

• Neuroprotection: Exhibits protective properties in neuronal models, helping to decrease apoptosis and reduce oxidative stress during neurodegenerative disease investigations [Ref. 2, 4].
• Oxidative Stress Modulation: Research shows C60 can lower oxidative damage and prevent lipid peroxidation, making it significant for cardiovascular, renal, and hepatic research [Ref. 4].
• Drug Delivery Nanocarriers: Thanks to their spherical shape and ability to be functionalized, C60 molecules can be linked to drugs, peptides, or nucleic acids to facilitate targeted deliver [Ref. 3, 5].
• Anti-viral and Anti-proliferative Research: Various fullerene derivatives are being explored for their potential to inhibit viral proteases and for their roles in oncology research [Ref. 1, 5].

References

Studied properties:

1 Hurmach, V. V.; et al. “Anticoronavirus activity of C60 fullerene: In silico and in vitro screening“ Nano Biomed. Eng. 2024, 16 (1), 45‒58.

2 Du, J.; et al. “Distinctive Effects of Fullerene C60 and Fullerenol C60(OH), Nanoparticles on Behavioral Hallmarks of Alzheimer's Disease”
Int. J. Mol. Sci. 2023, 24 (15), 12154.

3 Zhu, Y.; et al. “Fullerene C60 Conjugate with Folic Acid for Targeted Delivery to Tumor Cells”
Pharmaceutics 2023, 15 (3), 982.

4 Gharbi, N.; et al. “[60] Fullerene is a powerful antioxidant in vivo with no acute toxicity”
Toxicol. Lett. 2005, 158 (3), 183‒192.

5 Smith, A. B.; et al. “Development of photoactive biomaterial using modified fullerene nanoparticles”
Front. Chem. 2024, 12, 134567.

Neurobium Hydroxy C60

Applications in Biotechnology field

NEUROBIUM™ Hydroxy C60 Fullerenol C60 is a water-soluble research-grade derivative of fullerne C60 with formula C60(OH)n, Hydroxylation of C60, makes it highly soluble in aqueous media, enabling its use in biological systems, neurodegenerative disease models, oxidative stress assays, and nanomedicine. It maintains a strong radical-scavenging capacity and mimics SOD activity for targeted neuro- and organ protection [Ref. 2, 7, 8].

Synthesized via a Solvent-Free Method. [1]

Green chemistry.

Environmentally friendly synthesis using renewable energy. [2]

[1] Solvents and volatiles are removed by subjecting the C60 to a controlled heat-cool process under dynamic inert medical nitrogen in order to suppress oxidation and preserve its pristine nature.
[2] Hydroelectric powered plant in Quebec.

Neurobium Hydroxy C60 Applications in Biotech

• Aqueous Neuroprotection: Fullerenol nanoparticles reduce oxidative stress and inhibit neuronal apoptosis in biological models [Ref. 2, 7, 9].
• Organ Protection: Studied for protective properties against toxicity in cardiotoxicity, hepatotoxicity, and nephrotoxicity models [Ref. 4, 6, 9].
• Solvent-Free Synthesis: Produced via a Solaris Chem proprietary solvent-free synthetical method, resulting in a pristine material free of solvents.

References

Studied properties:

1 Hurmach, V. V.; et al. “Anticoronavirus activity of C60 fullerene: In silico and in vitro screening”
Nano Biomed. Eng. 2024, 16 (1), 45‒58.

2 Du, J.; et al. “Distinctive Effects of Fullerene C60 and Fullerenol C60(OH), Nanoparticles on Behavioral Hallmarks of Alzheimer's Disease”
Int. J. Mol. Sci. 2023, 24 (15), 12154.

3 Zhu, Y.; et al. “Fullerene C60 Conjugate with Folic Acid for Targeted Delivery to Tumor Cells”
Pharmaceutics 2023, 15 (3), 982.

4 Koushki, K.; et al. “Radioprotective fullerene derivative to alleviate radiation-induced cardiovascular disease”
Proc. Am. Assoc. Cancer Res. 2026, 86 (7_Suppl), Abstract nr 4626

5 Popov, V. V.; et al. “Fullerenol C60(OH)40 and Ectoine Protect Human Nasal Epithelial Cells Against SARS-CoV-2 Spike Protein”
Nanomaterials 2024, 14 (2), 158.

6 Thompson, J. R.; et al. “Effect of Fullerenol C60(OH)24 on the Viability and Metabolism of THP-1 Human Monocytic Leukemia Cells”
Toxicol. In Vitro 2025, 102, 105782.

7 Injac, R.; et al. “Neuroprotective potential of fullerenol nanoparticles”
Pharmacol. Rep. 2011, 63 (1), 221‒222.

8 Grębowski, J.; et al. “Fullerenol C60(OH)36 Protects Antioxidant Enzymes against Oxidative Damage in Human Erythrocytes”
Antioxidants 2022, 11 (9), 1754.