Description
WSC60MA – C60 Malonic Acid (SOL5163): Water-Soluble Fullerene Precursor
WSC60MA C60 malonic acid (SOL5163), or C60-n-(malonic acid), is a methanofullerene C60 derivative functionalized with malonic acid groups to achieve high solubility in basic aqueous media (pH > 7). Manufactured by Solaris Chem, WSC60MA bridges hydrophobic fullerene cages with biological systems, serving as a potent radical-sponge antioxidant, antiviral agent, and therapeutic scaffold.
Functionalization Levels and Customization (n > 3, 4, 5)
Solaris Chem provides controlled degrees of substitution for the SOL5163 precursor to match specific experimental protocols and drug delivery models:
- Level n > 3 (SOL5163A): Delivers an optimal balance between preserving core C60 electronic properties and achieving reliable water solubility.
- Level n > 4 (SOL5163B): Increases surface charge density, making it ideal for electrostatic biological interactions.
- Level n > 5 (SOL5163C): Highest functionalization grade, engineered for maximum solubility in basic water and long-term stability in complex chemical formulations.
Cutting-Edge Applications in Medicinal Research
1. Neuroprotection and Oxidative Stress
Functioning as a molecular “radical sponge,” WSC60MA neutralizes reactive oxygen species (ROS) associated with neuronal damage in neurodegenerative disease research (such as Alzheimer’s and Parkinson’s). Its water solubility allows seamless evaluation in biological cell assays.
2. Antiviral Properties (COVID-19 and Influenza)
Peer-reviewed literature demonstrates the ability of functionalized C60 derivatives to alter viral surfaces and disrupt transmission mechanisms for pathogens including COVID-19 and Influenza viruses, positioning SOL5163 as a key building block for advanced antiviral materials.
3. Oncology and Antiproliferative Agents
SOL5163 interacts directly with cell membranes and enzyme targets, making it a prime candidate in oncological research as an antiproliferative agent capable of inhibiting cancer cell growth.
Technical Documentation & SDS
Safety Data Sheet:
Download SDS-SOL5163 (PDF)
WSC60MA C60 Malonic Acid (SOL5163) Technical Specifications
| Property | Specification / Value |
|---|---|
| Acronyms | WSC60MA |
| Chemical Name | C60-n-(malonic acid), Water Soluble C60 |
| CAS Number | N/A |
| Appearance & Texture | Brown to black powder |
| Solubility | Water, basic (pH > 7) |
| Available Grades | SOL5163A (n > 3), SOL5163B (n > 4), SOL5163C (n > 5) |
Peer-Reviewed Scientific Citations
1. “Surface Alterations to Impart Antiviral Properties to Combat COVID‑19 Transmission” – Reshma Y. Siddiquie, Amit Agrawal, Suhas S. Joshi. Indian National Academy of Engineering (2020). https://doi.org/10.1007/s41403-020-00096-9
2. “Anti-Influenza Activity of C60 Fullerene Derivatives” – Masaki Shoji et al. PLoS ONE 8(6): e66337 (2013). https://doi.org/10.1371/journal.pone.0066337
Frequently Asked Questions (FAQ) – C60 Malonic Acid (WSC60MA)
What is WSC60MA C60 malonic acid (SOL5163) used for?
WSC60MA C60 malonic acid (SOL5163) is a water-soluble methanofullerene derivative used primarily in medicinal chemistry and nanotechnology. Key applications include neuroprotection against reactive oxygen species (ROS), antiviral studies (COVID-19 and Influenza), and oncological research as an antiproliferative agent.
What functionalization levels (n > 3, 4, 5) are available for SOL5163?
Solaris Chem offers three functionalization levels: Level n > 3 (SOL5163A) for balanced C60 core properties and solubility; Level n > 4 (SOL5163B) for increased surface charge density; and Level n > 5 (SOL5163C) for maximum aqueous solubility in basic media and complex drug formulations.
What is the solubility profile of WSC60MA C60 malonic acid?
WSC60MA is engineered for high solubility in basic aqueous media (water, pH > 7), enabling hydrophobic C60 carbon cages to interact directly with biological systems.
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Notice: Products for Research and Development. Laboratory use only by qualified personnel. The user should read the available SDS and be aware of any precautions to take for the safe manipulation of these materials. Solaris Chem shall not be held responsible for any damage resulting from handling or use.
