Neurovium C60

Neurovium and its applications in Pharmaceutical field

The NEUROVIUM C60 is a research-grade fullerene C60 engineered for applications in pharmaceutical and biotechnology research. With a unique hollow carbon-cage structure, fullerene C60 acts as a multi-radical scavenger, neutralizing reactive oxygen and nitrogen species and mimicking the activity of natural antioxidant enzymes such as superoxide dismutase (SOD).

Thanks to its small size, can easily cross the so-called blood-brain barrier. This property can lead to numerous medical applications, especially in the field of nanomedicines, through the implementation of new active compounds that could be used by the brain.

Fullerenes are relatively safe and inert, and yet have properties that allow the substance to create active derivatives.

Synthesized via a Solvent-Free Method. [1]

Green chemistry.

Environmentally friendly synthesis using renewable energy. [2]

[1] Solvents and volatiles are removed by subjecting the C60 to a controlled heat-cool process under dynamic inert medical nitrogen in order to suppress oxidation and preserve its pristine nature.
[2] Hydroelectric powered plant in Quebec.

Neurovium C60 Applications in Pharma

• Neuroprotection: Fullerenes and fullerenols have shown protective effects in neuronal models, reducing apoptosis and oxidative stress in neurodegenerative disease research.
• Oxidative Stress Modulation: Studies demonstrate fullerenes’ capacity to reduce oxidative damage and lipid peroxidation, relevant for cardiovascular, renal, and hepatic research.
• Drug Delivery Nanocarriers: The spherical structure and functionalizability of C60 enable conjugation with drugs, peptides, or nucleic acids for targeted delivery.
• Anti-viral and Anti-proliferative Research: Fullerene derivatives have been investigated for inhibitory effects on viral proteases and in oncology-related studies.
• Treatment of various neuronal problems.
• Development of new drugs for the brain, associating its antioxidant and antiaggregant properties.
• Biomedical applications, like the design of high-performance MRI contrast agents and X-ray imaging contrastagents. [A] [B]
• Light-activated antimicrobial agents. [C]
• Used as a carrier for gene and drug delivery systems.
• They are used for serum protein profiling as MELDI material for biomarker discovery.
• Potential antiviral activity, which has strong implications on the treatment of HIV-infection.
• Fullerenes can be made to be absorbed by HeLa cells. Recent experiments using HeLa cells in cancer research involves the development of new photosensitizers with increased ability to be absorbed by cancer cells and still trigger cell death. It is also important that a new photosensitizer does not stay in the body for a long time to prevent unwanted cell damage.

References

Studied properties:

1 Injac, R. et al. “Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity in rats”
(2009) Biomaterials.

2 Injac, R. et al. “Neuroprotective potential of fullerenol nanoparticles”
(2011) Pharmacol. Reports.

3 Gharbi, N. et al. “[60] Fullerene is a powerful antioxidant in vivo with no acute toxicity”
(2005) Toxicol. Lett.

4 Andrievsky, G.V. et al. “Study of aqueous fullerenol as a radical sponge”
(2002) J. Nanoscience Nanotech.

5 MST Nano. “Fullerenol nanoparticles: antioxidant and protective properties”
(2024) (neuro-, hepato-, nephroprotective).

A “Multifunctional fullerene and metallofullerene based nanobiomaterials”
Author(s): G. Lalwani and B. Sitharaman,NanoLIFE 08/2013; 3:1342003. DOI: 10.1142/S1793984413420038.

B “Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers”
Author(s): Tegos, G. P.; Demidova, T. N.; Arcila-Lopez, D.; Lee, H.; Wharton, T.; Gali, H.; Hamblin, M. R. (2005). Chemistry & Biology. 12 (10): 1127–1135. Ref: Cationic Fullerenes Are Effective and Selective Antimicrobial Photosensitizers

C “The present and future role of photodynamic therapy in cancer treatment“
Author(s): Brown, S.B.; Brown, E.A.; Walker, I. (2004). Lancet Oncology. 5 (8): 497–508. Ref: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(04)01529-3/fulltext

Neurovium WS C60

Applications in Pharmaceutical field

The NEUROVIUM WS C60 is a research-grade fullerenol C60(OH)x, the water-soluble derivative of fullerene C60, engineered for pharmaceutical and biotechnology research.

Hydroxylation makes C60 dispersible in aqueous media, enabling use in biological systems, neurodegenerative disease models, oxidative stress assays, and nanomedicine. With strong radical-scavenging capacity, fullerenol mimics superoxide dismutase (SOD) activity and has been studied for neuroprotection, organ protection, and drug delivery systems.

Many of the proposed fullerene applications are to be practical technologies in a wide range of areas such as IT devices, diagnostics, pharmaceuticals, environmental, and energy industries. The direct application of Fullerenol C60 and fullerene and their derivatives to biological targets is now yielding promising applications in medicine.

Such attention to them is caused by unique chemical and physical properties of the fullerene core, including their photodynamic properties. The hydrophobic spheroid and the radical sponge character of fullerene are responsible for the activity in different fields.

Synthesized via a Solvent-Free Method. [1]

Green chemistry.

Environmentally friendly synthesis using renewable energy. [2]

[1] Solvents and volatiles are removed by subjecting the C60 to a controlled heat-cool process under dynamic inert medical nitrogen in order to suppress oxidation and preserve its pristine nature.
[2] Hydroelectric powered plant in Quebec.

Neurovium WS C60 Applications in Pharma

• Neuroprotection: Fullerenol nanoparticles reduce oxidative stress, inhibit neuronal apoptosis, and show potential in models of neurodegenerative disease.
• Antimicrobial activity.
• Carrier for gene and drug delivery systems.
• Pro-oxidants.
• Cytotoxic or protective effect respectively against cancer cells or healthy cells.
• Transfer of contrast agents or in drug transport.
• Protect neurons in the particular areas of the brain.
• Application in neuroscience.
• Diagnostic application.
• In the future provide a solid alternative to currently used pharmacological methods in chemotherapy, treatment of neurodegenerative diseases and radiobiology.

References

Studied properties:

1 Injac, R. et al. “Fullerenol C60(OH)24 protects against doxorubicin-induced cardiotoxicity”
(2009) Biomaterials.

2 Injac, R. et al. “Neuroprotective potential of fullerenol nanoparticles in oxidative stress models”
(2011) Pharmacol. Reports.

3 Gharbi, N. et al. “[60] Fullerene and fullerenols are powerful antioxidants in vivo with no acute toxicity”
(2005) Toxicol. Lett.

4 Andrievsky, G.V. et al. “C60 fullerenols as radical sponges in aqueous systems”
(2002) J. Nanoscience Nanotech.

5 MST Nano. “Fullerenol nanoparticles: antioxidant, neuroprotective, and organ-protective effects”
(2024).

6 “Fullerenols as a New Therapeutic Approach in Nanomedicine”
Author(s): Jacek Grebowski (A), Paulina Kazmierska (B), and Anita Krokosz (A)
DOI: https://doi.org/10.1155/2013/751913

A. Department of Molecular Biophysics, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland.
B. Department of Neurobiology, Faculty of Biology and Environmental Protection, University of Lodz, ul. Pomorska 141/143, 90-236 Lodz, Poland.

7 “Synthesis and Biological Activity of Fullerenols with Various Contents of Hydroxyl Groups”
Author(s): M. Yu. Eropkin, E. Yu. Melenevskaya, K. V. Nasonova, T. S. Bryazzhikova, E. M. Eropkina, D. M. Danilenko & O. I. Kiselev. Pharmaceutical Chemistry Journal volume 47, pages87–91(2013) DOI: https://doi.org/10.1007/s11094-013-0901-x

8 “Fullerenols: Physicochemical properties and applications”
Author(s): lK.N.Semenov (A), N.A.Charykov (B), V.N.Postnov (A), V.V.Sharoyko (A), I.V.Vorotyntsev (C), M.M.Galagudza (D), I.V.Murin (A). DOI: https://doi.org/10.1016/j.progsolidstchem.2016.04.002

A. Saint Petersburg State University, 198504 St. Petersburg, Russia.
B. Saint Petersburg State Technological Institute (Technical University), 190013 St. Petersburg, Russia.
C. Nizhny Novgorod State Technical University n.a. R.E. Alekseev, Nanotechnology and Biotechnology Department, 603950 Nizhny Novgorod, Russia.
D. Federal North-West Medical Research Centre, Institute of Experimental Medicine, 197341 St. Petersburg, Russia.